DT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates

Study details

Source ID

https://identifiers.org/metabolights:MTBLS5005

Title

DT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates

Summary

DT-109 ameliorates NASH in nonhuman primates.

Observation

Effects of DT-109 on steatohepatitis and fibrosis in nonhuman primates.

Findings

DT-109 reverses hepatic steatosis and prevents fibrosis progression by modulating metabolism.

Disease terms

nonalcoholic steatohepatitis, hepatic steatosis, steatohepatitis, NASH, fibrosis, Nonalcoholic steatohepatitis

Gene terms

—

Chemical terms

Gly-Gly-Leu, glycine, fatty acid, glutathione, bile acid

Organisms

human, mice

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS5005.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0009062",
    "https://identifiers.org/GO:0006544",
    "https://identifiers.org/GO:0006750"
  ],
  "go_kw": [
    "fatty acid degradation",
    "glycine metabolism",
    "glutathione formation"
  ],
  "integmet_study": "MTBLS5005",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:C000591538",
    "https://identifiers.org/mesh:D005998",
    "https://identifiers.org/mesh:D005227",
    "https://identifiers.org/mesh:D005978",
    "https://identifiers.org/mesh:D001647"
  ],
  "mesh_chemical_pubtator_kw": [
    "Gly-Gly-Leu",
    "glycine",
    "fatty acid",
    "glutathione",
    "bile acid"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D065626",
    "https://identifiers.org/mesh:D005234",
    "https://identifiers.org/mesh:D005355"
  ],
  "mesh_disease_pubtator_kw": [
    "nonalcoholic steatohepatitis",
    "hepatic steatosis",
    "steatohepatitis",
    "NASH",
    "fibrosis",
    "Nonalcoholic steatohepatitis"
  ],
  "ncbi_taxonomy_id": [
    "https://identifiers.org/taxonomy:9606",
    "https://identifiers.org/taxonomy:10090"
  ],
  "ncbi_taxonomy_pubtator_kw": [
    "human",
    "mice"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS5005",
  "study_findings": "DT-109 reverses hepatic steatosis and prevents fibrosis progression by modulating metabolism.",
  "study_observation": "Effects of DT-109 on steatohepatitis and fibrosis in nonhuman primates.",
  "study_summary": "DT-109 ameliorates NASH in nonhuman primates.",
  "study_title_original": "DT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates"
}