Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation

Study details

Source ID

https://identifiers.org/metabolights:MTBLS3725

Title

Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation

Summary

Mechanical force enhances bone formation via Ddah1.

Observation

Mechanical force regulation of ADMA via Ddah1 in osteoblasts.

Findings

Mechanical force down-regulates ADMA, enhancing bone formation.

Disease terms

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Gene terms

Ddah1, dimethylarginine dimethylaminohydrolase 1, TAZ, SMAD4

Chemical terms

ADMA, asymmetric dimethylarginine

Organisms

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Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS3725.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0060348",
    "https://identifiers.org/GO:0001503",
    "https://identifiers.org/GO:0005737",
    "https://identifiers.org/GO:0006351",
    "https://identifiers.org/GO:0046849"
  ],
  "go_kw": [
    "bone development",
    "bone formation",
    "cytoplasm",
    "transcription",
    "bone remodeling"
  ],
  "integmet_study": "MTBLS3725",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:C018524"
  ],
  "mesh_chemical_pubtator_kw": [
    "ADMA",
    "asymmetric dimethylarginine"
  ],
  "mesh_gene_id": [
    "https://identifiers.org/ncbigene:23576",
    "https://identifiers.org/ncbigene:6901",
    "https://identifiers.org/ncbigene:4089"
  ],
  "mesh_gene_pubtator_kw": [
    "Ddah1",
    "dimethylarginine dimethylaminohydrolase 1",
    "TAZ",
    "SMAD4"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS3725",
  "study_findings": "Mechanical force down-regulates ADMA, enhancing bone formation.",
  "study_observation": "Mechanical force regulation of ADMA via Ddah1 in osteoblasts.",
  "study_summary": "Mechanical force enhances bone formation via Ddah1.",
  "study_title_original": "Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation"
}