Global Metabonomic and Proteomic Analysis of Human Conjunctival Epithelial Cells (IOBA-NHC) in Response to Hyperosmotic Stress

Study details

Source ID

https://identifiers.org/metabolights:MTBLS214

Title

Global Metabonomic and Proteomic Analysis of Human Conjunctival Epithelial Cells (IOBA-NHC) in Response to Hyperosmotic Stress

Summary

Metabonomic and proteomic analysis of IOBA-NHC cells.

Observation

Hyperosmotic stress-induced changes in metabolites and proteins in IOBA-NHC cells.

Findings

Identified glycerophosphocholine synthesis and O-linked β-N-acetylglucosamine glycosylation as key pathways.

Disease terms

inflammation, inflammatory, dry eye, Dry eye

Gene terms

—

Chemical terms

glycerophosphocholine

Organisms

Human, human

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS214.

{
  "@type": "Dataset",
  "integmet_study": "MTBLS214",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:D005997"
  ],
  "mesh_chemical_pubtator_kw": [
    "glycerophosphocholine"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D007249",
    "https://identifiers.org/mesh:D015352"
  ],
  "mesh_disease_pubtator_kw": [
    "inflammation",
    "inflammatory",
    "dry eye",
    "Dry eye"
  ],
  "ncbi_taxonomy_id": [
    "https://identifiers.org/taxonomy:9606"
  ],
  "ncbi_taxonomy_pubtator_kw": [
    "Human",
    "human"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS214",
  "study_findings": "Identified glycerophosphocholine synthesis and O-linked \u03b2-N-acetylglucosamine glycosylation as key pathways.",
  "study_observation": "Hyperosmotic stress-induced changes in metabolites and proteins in IOBA-NHC cells.",
  "study_summary": "Metabonomic and proteomic analysis of IOBA-NHC cells.",
  "study_title_original": "Global Metabonomic and Proteomic Analysis of Human Conjunctival Epithelial Cells (IOBA-NHC) in Response to Hyperosmotic Stress"
}