Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the developing brain

Study details

Source ID

https://identifiers.org/metabolights:MTBLS1952

Title

Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the developing brain

Summary

Omega-3 deficiency affects microglial phagocytosis.

Observation

Microglial phagocytosis of synaptic elements in the developing hippocampus

Findings

Maternal n-3 PUFA deficiency increases microglial phagocytosis, affecting neuronal morphology and cognition.

Disease terms

neurodevelopmental diseases, neurodevelopmental disorders, neurodevelopmental defects

Gene terms

12/15-lipoxygenase, LOX

Chemical terms

Omega-3 fatty acids, n-3 PUFA, n-3 PUFAs, 12-HETE

Organisms

mouse, mice, Humans

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS1952.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0023052",
    "https://identifiers.org/GO:0007420",
    "https://identifiers.org/GO:0006909"
  ],
  "go_kw": [
    "signaling",
    "brain development",
    "phagocytosis"
  ],
  "integmet_study": "MTBLS1952",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:D015525",
    "https://identifiers.org/mesh:D019377"
  ],
  "mesh_chemical_pubtator_kw": [
    "Omega-3 fatty acids",
    "n-3 PUFA",
    "n-3 PUFAs",
    "12-HETE"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D004194",
    "https://identifiers.org/mesh:D002658",
    "https://identifiers.org/mesh:D065886"
  ],
  "mesh_disease_pubtator_kw": [
    "neurodevelopmental diseases",
    "neurodevelopmental disorders",
    "neurodevelopmental defects"
  ],
  "mesh_gene_id": [
    "https://identifiers.org/ncbigene:11687"
  ],
  "mesh_gene_pubtator_kw": [
    "12/15-lipoxygenase",
    "LOX"
  ],
  "ncbi_taxonomy_id": [
    "https://identifiers.org/taxonomy:10090",
    "https://identifiers.org/taxonomy:9606"
  ],
  "ncbi_taxonomy_pubtator_kw": [
    "mouse",
    "mice",
    "Humans"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS1952",
  "study_findings": "Maternal n-3 PUFA deficiency increases microglial phagocytosis, affecting neuronal morphology and cognition.",
  "study_observation": "Microglial phagocytosis of synaptic elements in the developing hippocampus",
  "study_summary": "Omega-3 deficiency affects microglial phagocytosis.",
  "study_title_original": "Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the developing brain"
}