Comprehensive Metabolic Profiling of Age-Related Mitochondrial Dysfunction in the High-Fat-Fed ob/ob Mouse Heart

Study details

Source ID

https://identifiers.org/metabolights:MTBLS173

Title

Comprehensive Metabolic Profiling of Age-Related Mitochondrial Dysfunction in the High-Fat-Fed ob/ob Mouse Heart

Summary

Metabolic profiling of ob/ob mouse heart dysfunction.

Observation

Mitochondrial respiratory capacities in ob/ob and wild-type mice hearts.

Findings

Mitochondrial dysfunction in ob/ob mice linked to oxidative stress and complex I defect.

Disease terms

complex I defect, Mitochondrial Dysfunction, diabetic cardiomyopathy, mitochondrial dysfunction

Gene terms

ob, ob/

Chemical terms

GSSG, lipid, diacylglycerols, 8-oxoguanine, acylcarnitines, triglycerides, GSH

Organisms

Mouse, mice

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS173.

{
  "@type": "Dataset",
  "integmet_study": "MTBLS173",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:D019803",
    "https://identifiers.org/mesh:D008055",
    "https://identifiers.org/mesh:D004075",
    "https://identifiers.org/mesh:C024829",
    "https://identifiers.org/mesh:C116917",
    "https://identifiers.org/mesh:D014280",
    "https://identifiers.org/mesh:D005978"
  ],
  "mesh_chemical_pubtator_kw": [
    "GSSG",
    "lipid",
    "diacylglycerols",
    "8-oxoguanine",
    "acylcarnitines",
    "triglycerides",
    "GSH"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:C537475",
    "https://identifiers.org/mesh:D028361",
    "https://identifiers.org/mesh:D058065"
  ],
  "mesh_disease_pubtator_kw": [
    "complex I defect",
    "Mitochondrial Dysfunction",
    "diabetic cardiomyopathy",
    "mitochondrial dysfunction"
  ],
  "mesh_gene_id": [
    "https://identifiers.org/ncbigene:16846"
  ],
  "mesh_gene_pubtator_kw": [
    "ob",
    "ob/"
  ],
  "ncbi_taxonomy_id": [
    "https://identifiers.org/taxonomy:10090"
  ],
  "ncbi_taxonomy_pubtator_kw": [
    "Mouse",
    "mice"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS173",
  "study_findings": "Mitochondrial dysfunction in ob/ob mice linked to oxidative stress and complex I defect.",
  "study_observation": "Mitochondrial respiratory capacities in ob/ob and wild-type mice hearts.",
  "study_summary": "Metabolic profiling of ob/ob mouse heart dysfunction.",
  "study_title_original": "Comprehensive Metabolic Profiling of Age-Related Mitochondrial Dysfunction in the High-Fat-Fed ob/ob Mouse Heart"
}