Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs (T. brucei assay)

Study details

Source ID

https://identifiers.org/metabolights:MTBLS1474

Title

Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs (T. brucei assay)

Summary

Benzoxaboroles are peptidase-activated prodrugs against trypanosomes.

Observation

Trypanocidal benzoxaboroles activated by trypanosome serine carboxypeptidases.

Findings

CBP loss-of-function causes resistance; re-expression restores susceptibility.

Disease terms

nagana, Livestock diseases

Gene terms

—

Chemical terms

carboxylic acid, AN11736

Organisms

Trypanosoma congolense, T. brucei, T. congolense

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS1474.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0009315",
    "https://identifiers.org/GO:0004180"
  ],
  "go_kw": [
    "drug resistance",
    "carboxypeptidase activity"
  ],
  "integmet_study": "MTBLS1474",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:D002264",
    "https://identifiers.org/mesh:C000625879"
  ],
  "mesh_chemical_pubtator_kw": [
    "carboxylic acid",
    "AN11736"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D014353",
    "https://identifiers.org/mesh:D004194"
  ],
  "mesh_disease_pubtator_kw": [
    "nagana",
    "Livestock diseases"
  ],
  "ncbi_taxonomy_id": [
    "https://identifiers.org/taxonomy:5692",
    "https://identifiers.org/taxonomy:5691"
  ],
  "ncbi_taxonomy_pubtator_kw": [
    "Trypanosoma congolense",
    "T. brucei",
    "T. congolense"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS1474",
  "study_findings": "CBP loss-of-function causes resistance; re-expression restores susceptibility.",
  "study_observation": "Trypanocidal benzoxaboroles activated by trypanosome serine carboxypeptidases.",
  "study_summary": "Benzoxaboroles are peptidase-activated prodrugs against trypanosomes.",
  "study_title_original": "Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs (T. brucei assay)"
}