NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome (Intracellular UPLC-MS assay)

Study details

Source ID

https://identifiers.org/metabolights:MTBLS1223

Title

NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome (Intracellular UPLC-MS assay)

Summary

NAD+ restores mitophagy, limits aging in Werner syndrome.

Observation

Impaired mitophagy and NAD+ depletion in WS models.

Findings

NAD+ repletion restores mitophagy, extends lifespan in WS models.

Disease terms

Metabolic dysfunction, stem cell dysfunction, WS, Werner syndrome, mitochondrial function, premature aging disease, metabolic deficit

Gene terms

DCT-1, Werner, ULK-1, NMNAT1, WRN, nicotinamide nucleotide adenylyltransferase 1

Chemical terms

NAD+

Organisms

Drosophila melanogaster, patients, human, patient, Caenorhabditis elegans

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS1223.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0005739",
    "https://identifiers.org/GO:0005737",
    "https://identifiers.org/GO:0008152",
    "https://identifiers.org/GO:0005634",
    "https://identifiers.org/GO:0003678",
    "https://identifiers.org/GO:0006351",
    "https://identifiers.org/GO:0000423"
  ],
  "go_kw": [
    "mitochondrion",
    "cytoplasm",
    "metabolism",
    "nucleus",
    "DNA helicase activity",
    "transcription",
    "mitophagy"
  ],
  "integmet_study": "MTBLS1223",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:D009243"
  ],
  "mesh_chemical_pubtator_kw": [
    "NAD+"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D008659",
    "https://identifiers.org/mesh:D000092423",
    "https://identifiers.org/mesh:D014898",
    "https://identifiers.org/mesh:D028361",
    "https://identifiers.org/mesh:D019588",
    "https://identifiers.org/mesh:D009461"
  ],
  "mesh_disease_pubtator_kw": [
    "Metabolic dysfunction",
    "stem cell dysfunction",
    "WS",
    "Werner syndrome",
    "mitochondrial function",
    "premature aging disease",
    "metabolic deficit"
  ],
  "mesh_gene_id": [
    "https://identifiers.org/ncbigene:206358",
    "https://identifiers.org/ncbigene:7486",
    "https://identifiers.org/ncbigene:8408",
    "https://identifiers.org/ncbigene:64802"
  ],
  "mesh_gene_pubtator_kw": [
    "DCT-1",
    "Werner",
    "ULK-1",
    "NMNAT1",
    "WRN",
    "nicotinamide nucleotide adenylyltransferase 1"
  ],
  "ncbi_taxonomy_id": [
    "https://identifiers.org/taxonomy:7227",
    "https://identifiers.org/taxonomy:9606",
    "https://identifiers.org/taxonomy:6239"
  ],
  "ncbi_taxonomy_pubtator_kw": [
    "Drosophila melanogaster",
    "patients",
    "human",
    "patient",
    "Caenorhabditis elegans"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS1223",
  "study_findings": "NAD+ repletion restores mitophagy, extends lifespan in WS models.",
  "study_observation": "Impaired mitophagy and NAD+ depletion in WS models.",
  "study_summary": "NAD+ restores mitophagy, limits aging in Werner syndrome.",
  "study_title_original": "NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome (Intracellular UPLC-MS assay)"
}