Metabolomics reveals impaired maturation of HDL particles in adolescents with hyperinsulinaemic androgen excess

Study details

Source ID

https://identifiers.org/metabolights:MTBLS103

Title

Metabolomics reveals impaired maturation of HDL particles in adolescents with hyperinsulinaemic androgen excess

Summary

HDL maturation impaired in HIAE adolescents.

Observation

Serum levels of methionine sulfoxide in HIAE girls

Findings

Impaired HDL maturation linked to methionine-148 oxidation in apo-A1

Disease terms

hyperinsulinaemic androgen excess, anovulatory infertility, HIAE, metabolic syndrome, Hyperinsulinaemic androgen excess, hypertriglyceridemia, impaired glucose tolerance, hyperglycemia, type 2 diabetes

Gene terms

apo-A1, apolipoprotein-A1

Chemical terms

metformin, methionine sulfoxide, methionine, pioglitazone, flutamide

Organisms

—

Raw data (JSON) Show

Also available at /api/study/https://identifiers.org/metabolights:MTBLS103.

{
  "@type": "Dataset",
  "go_id": [
    "https://identifiers.org/GO:0006555"
  ],
  "go_kw": [
    "methionine metabolism"
  ],
  "integmet_study": "MTBLS103",
  "mesh_chemical_id": [
    "https://identifiers.org/mesh:D008687",
    "https://identifiers.org/mesh:C013111",
    "https://identifiers.org/mesh:D008715",
    "https://identifiers.org/mesh:D000077205",
    "https://identifiers.org/mesh:D005485"
  ],
  "mesh_chemical_pubtator_kw": [
    "metformin",
    "methionine sulfoxide",
    "methionine",
    "pioglitazone",
    "flutamide"
  ],
  "mesh_disease_id": [
    "https://identifiers.org/mesh:D014770",
    "https://identifiers.org/mesh:D007246",
    "https://identifiers.org/mesh:D024821",
    "https://identifiers.org/mesh:D015228",
    "https://identifiers.org/mesh:D018149",
    "https://identifiers.org/mesh:D006943",
    "https://identifiers.org/mesh:D003924"
  ],
  "mesh_disease_pubtator_kw": [
    "hyperinsulinaemic androgen excess",
    "anovulatory infertility",
    "HIAE",
    "metabolic syndrome",
    "Hyperinsulinaemic androgen excess",
    "hypertriglyceridemia",
    "impaired glucose tolerance",
    "hyperglycemia",
    "type 2 diabetes"
  ],
  "mesh_gene_id": [
    "https://identifiers.org/ncbigene:335"
  ],
  "mesh_gene_pubtator_kw": [
    "apo-A1",
    "apolipoprotein-A1"
  ],
  "source_id": "https://identifiers.org/metabolights:MTBLS103",
  "study_findings": "Impaired HDL maturation linked to methionine-148 oxidation in apo-A1",
  "study_observation": "Serum levels of methionine sulfoxide in HIAE girls",
  "study_summary": "HDL maturation impaired in HIAE adolescents.",
  "study_title_original": "Metabolomics reveals impaired maturation of HDL particles in adolescents with hyperinsulinaemic androgen excess"
}