{"@type":"Dataset","go_id":["https://identifiers.org/GO:0005739","https://identifiers.org/GO:0005737","https://identifiers.org/GO:0043490","https://identifiers.org/GO:0008219","https://identifiers.org/GO:0006526"],"go_kw":["mitochondrion","cytoplasm","malate-aspartate shuttle","cell death","arginine synthesis"],"integmet_study":"MTBLS745","mesh_chemical_id":["https://identifiers.org/mesh:D001120","https://identifiers.org/mesh:D001224","https://identifiers.org/mesh:C030298"],"mesh_chemical_pubtator_kw":["arginine","aspartate","malate","Arginine"],"mesh_disease_id":["https://identifiers.org/mesh:D012128","https://identifiers.org/mesh:D001943","https://identifiers.org/mesh:D009369","https://identifiers.org/mesh:D028361","https://identifiers.org/mesh:C567192"],"mesh_disease_pubtator_kw":["mitochondrial distress","breast cancer","cancer","tumor","mitochondrial dysfunction","arginine auxotrophy"],"mesh_gene_id":["https://identifiers.org/ncbigene:445","https://identifiers.org/ncbigene:440"],"mesh_gene_pubtator_kw":["argininosuccinate synthase 1","asparagine synthetase","ASNS","ASS1"],"source_id":"https://identifiers.org/metabolights:MTBLS745","study_findings":"Arginine starvation causes mitochondrial dysfunction and aspartate depletion, reducing tumor growth in ASS1-deficient breast cancer.","study_observation":"Effects of arginine depletion on arginine-auxotrophic cancer cells.","study_summary":"Arginine starvation kills cancer cells via aspartate depletion.","study_title_original":"Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction"}