{"@type":"Dataset","go_id":["https://identifiers.org/GO:0005739","https://identifiers.org/GO:0005737","https://identifiers.org/GO:0008152","https://identifiers.org/GO:0005634","https://identifiers.org/GO:0003678","https://identifiers.org/GO:0006351","https://identifiers.org/GO:0000423"],"go_kw":["mitochondrion","cytoplasm","metabolism","nucleus","DNA helicase activity","transcription","mitophagy"],"integmet_study":"MTBLS1223","mesh_chemical_id":["https://identifiers.org/mesh:D009243"],"mesh_chemical_pubtator_kw":["NAD+"],"mesh_disease_id":["https://identifiers.org/mesh:D008659","https://identifiers.org/mesh:D000092423","https://identifiers.org/mesh:D014898","https://identifiers.org/mesh:D028361","https://identifiers.org/mesh:D019588","https://identifiers.org/mesh:D009461"],"mesh_disease_pubtator_kw":["Metabolic dysfunction","stem cell dysfunction","WS","Werner syndrome","mitochondrial function","premature aging disease","metabolic deficit"],"mesh_gene_id":["https://identifiers.org/ncbigene:206358","https://identifiers.org/ncbigene:7486","https://identifiers.org/ncbigene:8408","https://identifiers.org/ncbigene:64802"],"mesh_gene_pubtator_kw":["DCT-1","Werner","ULK-1","NMNAT1","WRN","nicotinamide nucleotide adenylyltransferase 1"],"ncbi_taxonomy_id":["https://identifiers.org/taxonomy:7227","https://identifiers.org/taxonomy:9606","https://identifiers.org/taxonomy:6239"],"ncbi_taxonomy_pubtator_kw":["Drosophila melanogaster","patients","human","patient","Caenorhabditis elegans"],"source_id":"https://identifiers.org/metabolights:MTBLS1223","study_findings":"NAD+ repletion restores mitophagy, extends lifespan in WS models.","study_observation":"Impaired mitophagy and NAD+ depletion in WS models.","study_summary":"NAD+ restores mitophagy, limits aging in Werner syndrome.","study_title_original":"NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome (Intracellular UPLC-MS assay)"}