{"chebi_id":"29985","chebi_name":"L-glutamate(1\u2212)","chebi_synonyms":["L-glutamate","L-glutamic acid monoanion","hydrogen L-glutamate","(2S)-2-ammoniopentanedioate","L-glutamic acid, ion(1\u2212)"],"diffprof_id_observed":["MTBLS103_0001_00000001","MTBLS103_0002_00000001","MTBLS103_0003_00000001","MTBLS103_0004_00000001","MTBLS103_0005_00000001","MTBLS213_0001_00000001"],"diffprof_id_var_observed":["MTBLS103_0001_00000001","MTBLS103_0002_00000001","MTBLS103_0003_00000001","MTBLS103_0004_00000001","MTBLS103_0005_00000001"],"inchikey":"WHUUTDBJXJRKMK-VKHMYHEASA-M","inn_name":"","iupac_name":"hydrogen <small>L</small>-glutamate","num_study_observed":2,"reactome_ids":["R-HSA-112310","R-HSA-112313","R-HSA-112314","R-HSA-112315","R-HSA-112316","R-HSA-1266738","R-HSA-1428517","R-HSA-1430728","R-HSA-156580","R-HSA-156590","R-HSA-15869","R-HSA-1614558","R-HSA-1614635","R-HSA-162582","R-HSA-1643685","R-HSA-174403","R-HSA-196757","R-HSA-196807","R-HSA-196849","R-HSA-196854","R-HSA-210455","R-HSA-210500","R-HSA-211859","R-HSA-212436","R-HSA-2142691","R-HSA-2142753","R-HSA-2682334","R-HSA-352230","R-HSA-3700989","R-HSA-372790","R-HSA-379716","R-HSA-379724","R-HSA-379726","R-HSA-382551","R-HSA-388396","R-HSA-389661","R-HSA-392499","R-HSA-3928662","R-HSA-399710","R-HSA-399721","R-HSA-416476","R-HSA-418594","R-HSA-420499","R-HSA-422475","R-HSA-425407","R-HSA-438064","R-HSA-438066","R-HSA-442660","R-HSA-442742","R-HSA-442755","R-HSA-442982","R-HSA-446193","R-HSA-446203","R-HSA-446210","R-HSA-446219","R-HSA-451306","R-HSA-451307","R-HSA-451308","R-HSA-451326","R-HSA-499943","R-HSA-500657","R-HSA-500753","R-HSA-500792","R-HSA-5423646","R-HSA-556833","R-HSA-5578999","R-HSA-5579029","R-HSA-5619062","R-HSA-5619067","R-HSA-5619076","R-HSA-5619102","R-HSA-5619115","R-HSA-5628897","R-HSA-5663205","R-HSA-5668914","R-HSA-5673001","R-HSA-5683057","R-HSA-5684996","R-HSA-597592","R-HSA-611105","R-HSA-6794362","R-HSA-70263","R-HSA-70268","R-HSA-70326","R-HSA-70635","R-HSA-70688","R-HSA-70895","R-HSA-70921","R-HSA-71064","R-HSA-71240","R-HSA-71291","R-HSA-71387","R-HSA-72766","R-HSA-73817","R-HSA-73857","R-HSA-74160","R-HSA-8849932","R-HSA-888568","R-HSA-888590","R-HSA-8955332","R-HSA-8956320","R-HSA-8963684","R-HSA-8963691","R-HSA-8963693","R-HSA-8964539","R-HSA-8964540","R-HSA-8978868","R-HSA-9018677","R-HSA-9018678","R-HSA-9026395","R-HSA-9026762","R-HSA-9026766","R-HSA-916853","R-HSA-9617324","R-HSA-9620244","R-HSA-9658195","R-HSA-9659379","R-HSA-9662360","R-HSA-9662851","R-HSA-9664433","R-HSA-9664535","R-HSA-9675108","R-HSA-9709957","R-HSA-9717189","R-HSA-9717207","R-HSA-9748784","R-HSA-9748787","R-HSA-9753281","R-HSA-977347","R-HSA-9824443","R-HSA-9856872","R-HSA-9958863"],"reactome_names":["Neurotransmitter release cycle","Neurotransmitter uptake and metabolism In glial cells","Neurotransmitter receptors and postsynaptic signal transmission","Transmission across Chemical Synapses","Neuronal System","Developmental Biology","Aerobic respiration and respiratory electron transport","Metabolism","Phase II - Conjugation of compounds","Glutathione conjugation","Metabolism of nucleotides","Degradation of cysteine and homocysteine","Sulfur amino acid metabolism","Signal Transduction","Disease","Glutathione synthesis and recycling","Metabolism of folate and pterines","Nicotinate metabolism","Metabolism of water-soluble vitamins and cofactors","Metabolism of vitamins and cofactors","Astrocytic Glutamate-Glutamine Uptake And Metabolism","Glutamate Neurotransmitter Release Cycle","Biological oxidations","Generic Transcription Pathway","Synthesis of Leukotrienes (LT) and Eoxins (EX)","Arachidonate metabolism","EPH-Ephrin signaling","Amino acid transport across the plasma membrane","Transcriptional Regulation by TP53","Signaling by GPCR","Cytosolic tRNA aminoacylation","tRNA Aminoacylation","Mitochondrial tRNA aminoacylation","Transport of small molecules","GPCR downstream signalling","Glyoxylate metabolism and glycine degradation","Metabolism of proteins","EPHB-mediated forward signaling","Activation of AMPA receptors","Glutamate binding, activation of AMPA receptors and synaptic plasticity","G alpha (q) signalling events","G alpha (i) signalling events","Class C/3 (Metabotropic glutamate/pheromone receptors)","Axon guidance","SLC-mediated transmembrane transport","Post NMDA receptor activation events","Unblocking of NMDA receptors, glutamate binding and activation","SLC-mediated transport of neurotransmitters","CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling","Activation of NMDA receptors and postsynaptic events","Ras activation upon Ca2+ influx through NMDA receptor","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein","Asparagine N-linked glycosylation","Synthesis of UDP-N-acetyl-glucosamine","Synthesis of substrates in N-glycan biosythesis","Ionotropic activity of kainate receptors","Activation of Na-permeable kainate receptors","Activation of Ca-permeable Kainate Receptor","Activation of kainate receptors upon glutamate binding","Interconversion of nucleotide di- and triphosphates","Presynaptic function of Kainate receptors","Pyrimidine biosynthesis","GPCR ligand binding","Aflatoxin activation and detoxification","Metabolism of lipids","Defective GCLC causes HAGGSD","Metabolic disorders of biological oxidation enzymes","Defective SLC1A3 causes episodic ataxia 6 (EA6)","Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)","Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25)","SLC transporter disorders","Disorders of transmembrane transporters","TP53 Regulates Metabolic Genes","Infectious disease","Diseases of metabolism","RAF/MAP kinase cascade","MAPK family signaling cascades","MAPK1/MAPK3 signaling","Post-translational protein modification","Respiratory electron transport","Protein-protein interactions at synapses","Gluconeogenesis","Pyruvate metabolism","Glucose metabolism","Urea cycle","Proline catabolism","Branched-chain amino acid catabolism","Histidine catabolism","Lysine catabolism","Tryptophan catabolism","Metabolism of amino acids and derivatives","Metabolism of carbohydrates and carbohydrate derivatives","Translation","Purine ribonucleoside monophosphate biosynthesis","RNA Polymerase II Transcription","Gene expression (Transcription)","Synaptic adhesion-like molecules","GABA synthesis","GABA synthesis, release, reuptake and degradation","Carboxyterminal post-translational modifications of tubulin","Nucleotide biosynthesis","Tyrosine catabolism","Phenylalanine and tyrosine metabolism","Aspartate and asparagine metabolism","Glutamate and glutamine metabolism","Alanine metabolism","Fatty acid metabolism","Biosynthesis of DHA-derived SPMs","Biosynthesis of specialized proresolving mediators (SPMs)","Biosynthesis of DHA-derived sulfido conjugates","Biosynthesis of maresin conjugates in tissue regeneration (MCTR)","Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)","Degradation of GABA","Negative regulation of NMDA receptor-mediated neuronal transmission","Long-term potentiation","Leishmania infection","Sensory processing of sound","Sensory processing of sound by inner hair cells of the cochlea","Anti-inflammatory response favouring Leishmania parasite infection","Leishmania parasite growth and survival","LTC4-CYSLTR mediated IL4 production","Nervous system development","Sensory Perception","Sensory perception of taste","Sensory perception of sweet, bitter, and umami (glutamate) taste","Drug ADME","Azathioprine ADME","Paracetamol ADME","Serine metabolism","Parasitic Infection Pathways","Malate-aspartate shuttle","SLC-mediated transport of amino acids"],"study_id_observed":["MTBLS103","MTBLS213"],"study_id_var_observed":["MTBLS103"],"synonym_name":"L-glutamate"}