{"chebi_id":"78543","chebi_name":"ponatinib","chebi_synonyms":["AP24534","AP 24534","ponatinibum","3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide","AP-24534"],"diffprof_id_observed":["MTBLS4893_0003_00000003"],"diffprof_id_var_observed":[],"inchikey":"PHXJVRSECIGDHY-UHFFFAOYSA-N","inn_name":"ponatinib","iupac_name":"3-(imidazo[1,2-<em>b</em>]pyridazin-3-ylethynyl)-4-methyl-<em>N</em>-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide","num_study_observed":1,"reactome_ids":["R-HSA-1280215","R-HSA-1433557","R-HSA-162582","R-HSA-1643685","R-HSA-168256","R-HSA-186797","R-HSA-5213460","R-HSA-5218859","R-HSA-5357801","R-HSA-5663202","R-HSA-5663205","R-HSA-5675482","R-HSA-9006934","R-HSA-9607240","R-HSA-9669921","R-HSA-9669938","R-HSA-9671555","R-HSA-9674428","R-HSA-9679191","R-HSA-9679506","R-HSA-9682385","R-HSA-9702506","R-HSA-9702509","R-HSA-9702614","R-HSA-9824446"],"reactome_names":["Cytokine Signaling in Immune system","Signaling by SCF-KIT","Signal Transduction","Disease","Immune System","Signaling by PDGF","RIPK1-mediated regulated necrosis","Regulated Necrosis","Programmed Cell Death","Diseases of signal transduction by growth factor receptors and second messengers","Infectious disease","Regulation of necroptotic cell death","Signaling by Receptor Tyrosine Kinases","FLT3 Signaling","KIT mutants bind TKIs","Signaling by KIT in disease","Signaling by PDGFR in disease","PDGFR mutants bind TKIs","Potential therapeutics for SARS","SARS-CoV Infections","FLT3 signaling in disease","Drug resistance of FLT3 mutants","FLT3 mutants bind TKIs","ponatinib-resistant FLT3 mutants","Viral Infection Pathways"],"study_id_observed":["MTBLS4893"],"study_id_var_observed":[],"synonym_name":"AP24534"}