{"chebi_id":"16750","chebi_name":"guanosine","chebi_synonyms":["G","Guanosine","Guo","Guanosin","2-amino-9-\u03b2-D-ribofuranosyl-1,9-dihydro-6H-purin-6-one","9-\u03b2-D-ribofuranosyl-guanine","2(3H)-imino-9-\u03b2-D-ribofuranosyl-9H-purin-6(1H)-one","Guanine riboside","2-amino-1,9-dihydro-9-\u03b2-D-ribofuranosyl-6H-purin-6-one","Guanine-9-\u03b2-D-ribofuranoside"],"diffprof_id_observed":["MTBLS1182_0001_00000001","MTBLS1191_0001_00000001","MTBLS1191_0002_00000001","MTBLS125_0001_00000005","MTBLS125_0002_00000005","MTBLS127_0001_00000027","MTBLS127_0002_00000027","MTBLS127_0003_00000002","MTBLS127_0004_00000002","MTBLS127_0005_00000002","MTBLS127_0005_00000027","MTBLS1411_0001_00000001","MTBLS1698_0002_00000001","MTBLS181_0001_00000002","MTBLS2015_0002_00000001","MTBLS2145_0001_00000029","MTBLS2145_0003_00000029","MTBLS2145_0006_00000029","MTBLS2279_0001_00000005","MTBLS2322_0001_00000001","MTBLS2322_0002_00000001","MTBLS2324_0002_00000001","MTBLS2384_0002_00000005","MTBLS23_0001_00000001","MTBLS2406_0001_00000009","MTBLS2737_0002_00000003","MTBLS2771_0001_00000002","MTBLS2782_0002_00000009","MTBLS2825_0001_00000004","MTBLS2825_0002_00000004","MTBLS2878_0002_00000001","MTBLS293_0001_00000005","MTBLS293_0002_00000005","MTBLS2945_0002_00000003","MTBLS295_0002_00000001","MTBLS297_0001_00000001","MTBLS3003_0001_00000001","MTBLS3038_0002_00000001","MTBLS303_0002_00000006","MTBLS3056_0002_00000001","MTBLS312_0002_00000009","MTBLS3306_0001_00000014","MTBLS3306_0002_00000014","MTBLS3318_0001_00000001","MTBLS338_0001_00000001","MTBLS353_0001_00000001","MTBLS3540_0001_00000002","MTBLS359_0001_00000005","MTBLS3637_0001_00000001","MTBLS3657_0001_00000003","MTBLS3725_0001_00000003","MTBLS3750_0001_00000006","MTBLS376_0001_00000001","MTBLS376_0003_00000001","MTBLS37_0001_00000005","MTBLS3854_0001_00000001","MTBLS3927_0001_00000001","MTBLS3927_0002_00000001","MTBLS3935_0001_00000003","MTBLS3963_0002_00000001","MTBLS403_0001_00000008","MTBLS4046_0002_00000014","MTBLS4099_0001_00000001","MTBLS4099_0002_00000001","MTBLS4186_0001_00000001","MTBLS4249_0001_00000001","MTBLS4365_0001_00000002","MTBLS4469_0001_00000001","MTBLS4579_0001_00000001","MTBLS4722_0001_00000001","MTBLS4820_0002_00000001","MTBLS4893_0001_00000003","MTBLS4893_0002_00000003","MTBLS4894_0001_00000003","MTBLS4932_0001_00000005","MTBLS4967_0001_00000003","MTBLS4980_0002_00000006","MTBLS5132_0001_00000014","MTBLS5148_0001_00000014","MTBLS5335_0001_00000003","MTBLS5335_0003_00000003","MTBLS533_0001_00000001","MTBLS545_0001_00000001","MTBLS545_0002_00000001","MTBLS545_0003_00000001","MTBLS5462_0001_00000002","MTBLS5462_0001_00000050","MTBLS5462_0001_00000089","MTBLS5462_0001_00000119","MTBLS5462_0001_00000140","MTBLS5462_0001_00000152","MTBLS5971_0001_00000001","MTBLS6337_0001_00000002","MTBLS6402_0001_00000001","MTBLS6516_0001_00000002","MTBLS656_0001_00000031","MTBLS6661_0001_00000001","MTBLS686_0001_00000001","MTBLS6886_0001_00000001","MTBLS6890_0001_00000001","MTBLS6927_0001_00000001","MTBLS745_0001_00000002","MTBLS7584_0001_00000003","MTBLS7584_0002_00000003","MTBLS7711_0001_00000003","MTBLS7713_0001_00000003","MTBLS795_0001_00000001","MTBLS873_0001_00000002","MTBLS87_0001_00000001","MTBLS87_0002_00000001","MTBLS87_0004_00000001","MTBLS88_0001_00000001","MTBLS88_0003_00000001"],"diffprof_id_var_observed":["MTBLS1182_0001_00000001","MTBLS1191_0001_00000001","MTBLS1191_0002_00000001","MTBLS1411_0001_00000001","MTBLS1698_0002_00000001","MTBLS181_0001_00000002","MTBLS2015_0002_00000001","MTBLS2145_0001_00000029","MTBLS2322_0002_00000001","MTBLS2324_0002_00000001","MTBLS2384_0002_00000005","MTBLS23_0001_00000001","MTBLS2771_0001_00000002","MTBLS2825_0001_00000004","MTBLS2825_0002_00000004","MTBLS2878_0002_00000001","MTBLS295_0002_00000001","MTBLS297_0001_00000001","MTBLS3038_0002_00000001","MTBLS3056_0002_00000001","MTBLS3318_0001_00000001","MTBLS353_0001_00000001","MTBLS3657_0001_00000003","MTBLS3750_0001_00000006","MTBLS376_0001_00000001","MTBLS376_0003_00000001","MTBLS3854_0001_00000001","MTBLS4046_0002_00000014","MTBLS4099_0001_00000001","MTBLS4099_0002_00000001","MTBLS4249_0001_00000001","MTBLS4893_0001_00000003","MTBLS4893_0002_00000003","MTBLS4932_0001_00000005","MTBLS5335_0001_00000003","MTBLS5335_0003_00000003","MTBLS5971_0001_00000001","MTBLS6337_0001_00000002","MTBLS6661_0001_00000001","MTBLS686_0001_00000001","MTBLS7584_0002_00000003","MTBLS87_0001_00000001","MTBLS87_0002_00000001","MTBLS87_0004_00000001","MTBLS88_0001_00000001","MTBLS88_0003_00000001"],"inchikey":"NYHBQMYGNKIUIF-UUOKFMHZSA-N","inn_name":"","iupac_name":"guanosine","num_study_observed":84,"reactome_ids":["R-HSA-1430728","R-HSA-15869","R-HSA-1643685","R-HSA-168138","R-HSA-168181","R-HSA-168249","R-HSA-168256","R-HSA-168898","R-HSA-382551","R-HSA-425397","R-HSA-425407","R-HSA-5260271","R-HSA-5602358","R-HSA-5619063","R-HSA-5619102","R-HSA-5619115","R-HSA-5668914","R-HSA-5686938","R-HSA-74217","R-HSA-74259","R-HSA-83936","R-HSA-8956319","R-HSA-8956321","R-HSA-9735763","R-HSA-9735786","R-HSA-9735804","R-HSA-975110","R-HSA-975138","R-HSA-975155","R-HSA-9824856"],"reactome_names":["Metabolism","Metabolism of nucleotides","Disease","Toll Like Receptor 9 (TLR9) Cascade","Toll Like Receptor 7/8 (TLR7/8) Cascade","Innate Immune System","Immune System","Toll-like Receptor Cascades","Transport of small molecules","Transport of vitamins, nucleosides, and related molecules","SLC-mediated transmembrane transport","Diseases of Immune System","Diseases associated with the TLR signaling cascade","Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS)","SLC transporter disorders","Disorders of transmembrane transporters","Diseases of metabolism","Regulation of TLR by endogenous ligand","Purine salvage","Purine catabolism","Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane","Nucleotide catabolism","Nucleotide salvage","Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine","Nucleotide catabolism defects","Diseases of nucleotide metabolism","TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling","TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation","MyD88 dependent cascade initiated on endosome","Defective regulation of TLR7 by endogenous ligand"],"study_id_observed":["MTBLS1182","MTBLS1191","MTBLS125","MTBLS127","MTBLS1411","MTBLS1698","MTBLS181","MTBLS2015","MTBLS2145","MTBLS2279","MTBLS23","MTBLS2322","MTBLS2324","MTBLS2384","MTBLS2406","MTBLS2737","MTBLS2771","MTBLS2782","MTBLS2825","MTBLS2878","MTBLS293","MTBLS2945","MTBLS295","MTBLS297","MTBLS3003","MTBLS303","MTBLS3038","MTBLS3056","MTBLS312","MTBLS3306","MTBLS3318","MTBLS338","MTBLS353","MTBLS3540","MTBLS359","MTBLS3637","MTBLS3657","MTBLS37","MTBLS3725","MTBLS3750","MTBLS376","MTBLS3854","MTBLS3927","MTBLS3935","MTBLS3963","MTBLS403","MTBLS4046","MTBLS4099","MTBLS4186","MTBLS4249","MTBLS4365","MTBLS4469","MTBLS4579","MTBLS4722","MTBLS4820","MTBLS4893","MTBLS4894","MTBLS4932","MTBLS4967","MTBLS4980","MTBLS5132","MTBLS5148","MTBLS533","MTBLS5335","MTBLS545","MTBLS5462","MTBLS5971","MTBLS6337","MTBLS6402","MTBLS6516","MTBLS656","MTBLS6661","MTBLS686","MTBLS6886","MTBLS6890","MTBLS6927","MTBLS745","MTBLS7584","MTBLS7711","MTBLS7713","MTBLS795","MTBLS87","MTBLS873","MTBLS88"],"study_id_var_observed":["MTBLS1182","MTBLS1191","MTBLS1411","MTBLS1698","MTBLS181","MTBLS2015","MTBLS2145","MTBLS23","MTBLS2322","MTBLS2324","MTBLS2384","MTBLS2771","MTBLS2825","MTBLS2878","MTBLS295","MTBLS297","MTBLS3038","MTBLS3056","MTBLS3318","MTBLS353","MTBLS3657","MTBLS3750","MTBLS376","MTBLS3854","MTBLS4046","MTBLS4099","MTBLS4249","MTBLS4893","MTBLS4932","MTBLS5335","MTBLS5971","MTBLS6337","MTBLS6661","MTBLS686","MTBLS7584","MTBLS87","MTBLS88"],"synonym_name":"G"}