{"chebi_id":"59789","chebi_name":"S-adenosyl-L-methionine zwitterion","chebi_synonyms":["[(3S)-3-azaniumyl-3-carboxylatopropyl](5'-deoxyadenosin-5'-yl)(methyl)sulfonium","S-adenosyl-L-methionine"],"diffprof_id_observed":["MTBLS106_0001_00000001","MTBLS1167_0002_00000001","MTBLS1191_0001_00000001","MTBLS125_0001_00000005","MTBLS125_0002_00000005","MTBLS127_0001_00000027","MTBLS127_0002_00000027","MTBLS127_0003_00000002","MTBLS127_0004_00000002","MTBLS2108_0002_00000001","MTBLS2145_0001_00000029","MTBLS2145_0006_00000029","MTBLS214_0003_00000002","MTBLS2559_0001_00000001","MTBLS2771_0001_00000002","MTBLS2825_0002_00000004","MTBLS293_0001_00000005","MTBLS293_0002_00000005","MTBLS295_0001_00000001","MTBLS295_0002_00000001","MTBLS303_0002_00000006","MTBLS316_0002_00000009","MTBLS3540_0001_00000002","MTBLS3657_0001_00000003","MTBLS3854_0001_00000001","MTBLS3854_0002_00000001","MTBLS3935_0001_00000003","MTBLS4249_0001_00000001","MTBLS4463_0001_00000001","MTBLS45_0001_00000001","MTBLS549_0002_00000006","MTBLS6516_0002_00000002","MTBLS6661_0002_00000001","MTBLS67_0002_00000003","MTBLS708_0002_00000002","MTBLS87_0005_00000001","MTBLS88_0004_00000001"],"diffprof_id_var_observed":["MTBLS127_0002_00000027","MTBLS127_0003_00000002","MTBLS2145_0001_00000029","MTBLS2145_0006_00000029","MTBLS214_0003_00000002","MTBLS2559_0001_00000001","MTBLS2771_0001_00000002","MTBLS295_0001_00000001","MTBLS295_0002_00000001","MTBLS303_0002_00000006","MTBLS316_0002_00000009","MTBLS3540_0001_00000002","MTBLS3657_0001_00000003","MTBLS3854_0002_00000001","MTBLS4463_0001_00000001","MTBLS88_0004_00000001"],"inchikey":"MEFKEPWMEQBLKI-AIRLBKTGSA-O","inn_name":"","iupac_name":"[(3<i>S</i>)-3-azaniumyl-3-carboxylatopropyl](5'-deoxyadenosin-5'-yl)(methyl)sulfonium","num_study_observed":29,"reactome_ids":["R-HSA-112311","R-HSA-112315","R-HSA-112316","R-HSA-1266738","R-HSA-1280218","R-HSA-1428517","R-HSA-1430728","R-HSA-1474165","R-HSA-1483191","R-HSA-1483206","R-HSA-1483257","R-HSA-1500620","R-HSA-1500931","R-HSA-156580","R-HSA-156581","R-HSA-1614635","R-HSA-162582","R-HSA-163841","R-HSA-1640170","R-HSA-1643685","R-HSA-168256","R-HSA-191859","R-HSA-194441","R-HSA-195721","R-HSA-196741","R-HSA-196807","R-HSA-196849","R-HSA-196854","R-HSA-201681","R-HSA-201722","R-HSA-203927","R-HSA-209776","R-HSA-209905","R-HSA-209931","R-HSA-211000","R-HSA-211859","R-HSA-212165","R-HSA-212300","R-HSA-212436","R-HSA-2142789","R-HSA-2187338","R-HSA-2262752","R-HSA-2299718","R-HSA-2408499","R-HSA-2408508","R-HSA-2408522","R-HSA-2408552","R-HSA-2514856","R-HSA-2514859","R-HSA-2559580","R-HSA-2559582","R-HSA-2559583","R-HSA-3214841","R-HSA-3214858","R-HSA-3247509","R-HSA-3296469","R-HSA-3296482","R-HSA-3359467","R-HSA-351202","R-HSA-3700989","R-HSA-379397","R-HSA-379398","R-HSA-379401","R-HSA-382551","R-HSA-388841","R-HSA-389661","R-HSA-389948","R-HSA-392499","R-HSA-418990","R-HSA-421270","R-HSA-425407","R-HSA-427359","R-HSA-427389","R-HSA-427413","R-HSA-446728","R-HSA-453274","R-HSA-4839726","R-HSA-5250913","R-HSA-5250941","R-HSA-5334118","R-HSA-5358493","R-HSA-549127","R-HSA-556833","R-HSA-5578995","R-HSA-5579029","R-HSA-5601884","R-HSA-5633007","R-HSA-5663205","R-HSA-5668914","R-HSA-5673001","R-HSA-5676934","R-HSA-5683057","R-HSA-5684996","R-HSA-5693532","R-HSA-5693565","R-HSA-5693606","R-HSA-597592","R-HSA-6782315","R-HSA-6782861","R-HSA-6787450","R-HSA-6790901","R-HSA-6793080","R-HSA-6804760","R-HSA-68875","R-HSA-68886","R-HSA-69273","R-HSA-69275","R-HSA-69278","R-HSA-70921","R-HSA-71288","R-HSA-71291","R-HSA-71403","R-HSA-72086","R-HSA-72306","R-HSA-72312","R-HSA-72764","R-HSA-72766","R-HSA-73857","R-HSA-73894","R-HSA-74160","R-HSA-8868766","R-HSA-8868773","R-HSA-8876725","R-HSA-8878171","R-HSA-8936459","R-HSA-8939211","R-HSA-8939236","R-HSA-8953854","R-HSA-8953897","R-HSA-8978934","R-HSA-9006931","R-HSA-9009391","R-HSA-912446","R-HSA-947581","R-HSA-9638737","R-HSA-9639288","R-HSA-9640148","R-HSA-9645723","R-HSA-9648002","R-HSA-9678108","R-HSA-9679506","R-HSA-9679514","R-HSA-9682706","R-HSA-9682708","R-HSA-9694516","R-HSA-9694631","R-HSA-9694635","R-HSA-9694682","R-HSA-9694686","R-HSA-9694786","R-HSA-9709957","R-HSA-9710421","R-HSA-9711097","R-HSA-9748784","R-HSA-9748787","R-HSA-9759218","R-HSA-9759476","R-HSA-9764265","R-HSA-9764274","R-HSA-9764560","R-HSA-9764725","R-HSA-9772572","R-HSA-9772573","R-HSA-9816359","R-HSA-9818564","R-HSA-9820952","R-HSA-9820965","R-HSA-9821993","R-HSA-9824439","R-HSA-9824446","R-HSA-9828642","R-HSA-9841922","R-HSA-9842860","R-HSA-9843940","R-HSA-9843970","R-HSA-9845323","R-HSA-9851695","R-HSA-9854311","R-HSA-9857492","R-HSA-9909648","R-HSA-9909649","R-HSA-9913143","R-HSA-9917777","R-HSA-9937008"],"reactome_names":["Neurotransmitter clearance","Transmission across Chemical Synapses","Neuronal System","Developmental Biology","Adaptive Immune System","Aerobic respiration and respiratory electron transport","Metabolism","Reproduction","Synthesis of PC","Glycerophospholipid biosynthesis","Phospholipid metabolism","Meiosis","Cell-Cell communication","Phase II - Conjugation of compounds","Methylation","Sulfur amino acid metabolism","Signal Transduction","Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation","Cell Cycle","Disease","Immune System","snRNP Assembly","Metabolism of non-coding RNA","Signaling by WNT","Cobalamin (Cbl, vitamin B12) transport and metabolism","Nicotinate metabolism","Metabolism of water-soluble vitamins and cofactors","Metabolism of vitamins and cofactors","TCF dependent signaling in response to WNT","Formation of the beta-catenin:TCF transactivating complex","MicroRNA (miRNA) biogenesis","Metabolism of amine-derived hormones","Catecholamine biosynthesis","Serotonin and melatonin biosynthesis","Gene Silencing by RNA","Biological oxidations","Epigenetic regulation of gene expression","PRC2 methylates histones and DNA","Generic Transcription Pathway","Ubiquinol biosynthesis","Visual phototransduction","Cellular responses to stress","Condensation of Prophase Chromosomes","Formation of selenosugars for excretion","Metabolism of ingested SeMet, Sec, MeSec into H2Se","Selenoamino acid metabolism","Methylation of MeSeH for excretion","The phototransduction cascade","Inactivation, recovery and regulation of the phototransduction cascade","Oxidative Stress Induced Senescence","Senescence-Associated Secretory Phenotype (SASP)","Cellular Senescence","PKMTs methylate histone lysines","RMTs methylate histone arginines","Chromatin modifying enzymes","Defects in cobalamin (B12) metabolism","Defects in vitamin and cofactor metabolism","Defective MTRR causes HMAE","Metabolism of polyamines","Transcriptional Regulation by TP53","Enzymatic degradation of dopamine by COMT","Enzymatic degradation of Dopamine by monoamine oxidase","Dopamine clearance from the synaptic cleft","Transport of small molecules","Regulation of T cell activation by CD28 family","Glyoxylate metabolism and glycine degradation","Co-inhibition by PD-1","Metabolism of proteins","Adherens junctions interactions","Cell-cell junction organization","SLC-mediated transmembrane transport","SIRT1 negatively regulates rRNA expression","ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression","NoRC negatively regulates rRNA expression","Cell junction organization","Mitotic G2-G2/M phases","Chromatin organization","Positive epigenetic regulation of rRNA expression","Negative epigenetic regulation of rRNA expression","DNA methylation","Synthesis of diphthamide-EEF2","SLC-mediated transport of organic cations","Metabolism of lipids","Defective TPMT causes TPMT deficiency","Metabolic disorders of biological oxidation enzymes","PIWI-interacting RNA (piRNA) biogenesis","Regulation of TP53 Activity","Infectious disease","Diseases of metabolism","RAF/MAP kinase cascade","Protein repair","MAPK family signaling cascades","MAPK1/MAPK3 signaling","DNA Double-Strand Break Repair","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks","DNA Double Strand Break Response","Post-translational protein modification","tRNA modification in the nucleus and cytosol","Synthesis of wybutosine at G37 of tRNA(Phe)","tRNA modification in the mitochondrion","rRNA modification in the nucleus and cytosol","rRNA modification in the mitochondrion","Regulation of TP53 Activity through Methylation","Mitotic Prophase","M Phase","Cyclin A/B1/B2 associated events during G2/M transition","G2/M Transition","Cell Cycle, Mitotic","Histidine catabolism","Creatine metabolism","Metabolism of amino acids and derivatives","Citric acid cycle (TCA cycle)","mRNA Capping","tRNA processing","rRNA processing","Eukaryotic Translation Termination","Translation","RNA Polymerase II Transcription","DNA Repair","Gene expression (Transcription)","rRNA processing in the mitochondrion","rRNA processing in the nucleus and cytosol","Protein methylation","Transcriptional regulation by RUNX1","RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","ESR-mediated signaling","RUNX1 regulates transcription of genes involved in differentiation of HSCs","Metabolism of RNA","Cellular responses to stimuli","Metabolism of cofactors","Signaling by Nuclear Receptors","Extra-nuclear estrogen signaling","Meiotic recombination","Molybdenum cofactor biosynthesis","Action of antimicrobials and antimicrobial resistance","Amino acids regulate mTORC1","Infection with Enterobacteria","Diseases of programmed cell death","RAS processing","SARS-CoV-1 Infection","SARS-CoV Infections","SARS-CoV-1 Genome Replication and Transcription","Replication of the SARS-CoV-1 genome","Transcription of SARS-CoV-1 sgRNAs","SARS-CoV-2 Infection","Maturation of nucleoprotein","Translation of Structural Proteins","SARS-CoV-2 Genome Replication and Transcription","Replication of the SARS-CoV-2 genome","Transcription of SARS-CoV-2 sgRNAs","Sensory Perception","Defective pyroptosis","Cellular response to starvation","Drug ADME","Azathioprine ADME","Cobalamin (Cbl) metabolism","Regulation of Homotypic Cell-Cell Adhesion","Regulation of CDH1 Expression and Function","Regulation of Expression and Function of Type I Classical Cadherins","Regulation of CDH1 Gene Transcription","Negative Regulation of CDH1 Gene Transcription","Early SARS-CoV-2 Infection Events","Late SARS-CoV-2 Infection Events","Maternal to zygotic transition (MZT)","Epigenetic regulation of gene expression by MLL3 and MLL4 complexes","Respiratory Syncytial Virus Infection Pathway","Respiratory syncytial virus (RSV) genome replication, transcription and translation","Replacement of protamines by nucleosomes in the male pronucleus","Bacterial Infection Pathways","Viral Infection Pathways","Respiratory syncytial virus genome transcription","MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis","Regulation of endogenous retroelements","Regulation of endogenous retroelements by KRAB-ZFP proteins","Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex","Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)","Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes","Maturation of TCA enzymes and regulation of TCA cycle","Protein lipoylation","Regulation of PD-L1(CD274) expression","Regulation of PD-L1(CD274) transcription","Antimicrobial resistance","Epigenetic regulation by WDR5-containing histone modifying complexes","Mitochondrial mRNA modification"],"study_id_observed":["MTBLS106","MTBLS1167","MTBLS1191","MTBLS125","MTBLS127","MTBLS2108","MTBLS214","MTBLS2145","MTBLS2559","MTBLS2771","MTBLS2825","MTBLS293","MTBLS295","MTBLS303","MTBLS316","MTBLS3540","MTBLS3657","MTBLS3854","MTBLS3935","MTBLS4249","MTBLS4463","MTBLS45","MTBLS549","MTBLS6516","MTBLS6661","MTBLS67","MTBLS708","MTBLS87","MTBLS88"],"study_id_var_observed":["MTBLS127","MTBLS214","MTBLS2145","MTBLS2559","MTBLS2771","MTBLS295","MTBLS303","MTBLS316","MTBLS3540","MTBLS3657","MTBLS3854","MTBLS4463","MTBLS88"],"synonym_name":"S-adenosyl-L-methionine"}