{"chebi_id":"16810","chebi_name":"2-oxoglutarate(2\u2212)","chebi_synonyms":["2-ketoglutarate","2-oxopentanedioic acid, ion(2\u2212)","\u03b1-ketoglutarate","2-oxopentanedioate","2-oxoglutarate"],"diffprof_id_observed":["MTBLS30_0002_00000002","MTBLS67_0001_00000003","MTBLS87_0004_00000001","MTBLS88_0003_00000001"],"diffprof_id_var_observed":["MTBLS67_0001_00000003"],"inchikey":"KPGXRSRHYNQIFN-UHFFFAOYSA-L","inn_name":"","iupac_name":"2-oxopentanedioate","num_study_observed":4,"reactome_ids":["R-HSA-112122","R-HSA-112126","R-HSA-112310","R-HSA-112315","R-HSA-112316","R-HSA-1234174","R-HSA-1234176","R-HSA-1266738","R-HSA-1428517","R-HSA-1430728","R-HSA-1474244","R-HSA-1474290","R-HSA-1614558","R-HSA-1614635","R-HSA-162582","R-HSA-163841","R-HSA-1640170","R-HSA-1643685","R-HSA-1650814","R-HSA-194315","R-HSA-195258","R-HSA-196854","R-HSA-212165","R-HSA-2262752","R-HSA-2299718","R-HSA-2559580","R-HSA-2559583","R-HSA-2978092","R-HSA-3214842","R-HSA-3247509","R-HSA-372790","R-HSA-373076","R-HSA-382551","R-HSA-388396","R-HSA-389542","R-HSA-389599","R-HSA-389661","R-HSA-390918","R-HSA-392499","R-HSA-418594","R-HSA-425407","R-HSA-428643","R-HSA-4839726","R-HSA-500792","R-HSA-5221030","R-HSA-556833","R-HSA-561048","R-HSA-5625740","R-HSA-5625886","R-HSA-5668914","R-HSA-597592","R-HSA-611105","R-HSA-6782315","R-HSA-6782861","R-HSA-68875","R-HSA-68886","R-HSA-69278","R-HSA-70263","R-HSA-70268","R-HSA-70326","R-HSA-70895","R-HSA-71064","R-HSA-71240","R-HSA-71262","R-HSA-71291","R-HSA-71387","R-HSA-71403","R-HSA-72306","R-HSA-73894","R-HSA-73942","R-HSA-73943","R-HSA-74160","R-HSA-880009","R-HSA-888590","R-HSA-8953854","R-HSA-8953897","R-HSA-8963684","R-HSA-8963691","R-HSA-8963693","R-HSA-8964539","R-HSA-8964540","R-HSA-8978868","R-HSA-8978934","R-HSA-916853","R-HSA-9629569","R-HSA-9716542","R-HSA-977347","R-HSA-9816359","R-HSA-9821002","R-HSA-9853506","R-HSA-9856872","R-HSA-9955298"],"reactome_names":["ALKBH2 mediated reversal of alkylation damage","ALKBH3 mediated reversal of alkylation damage","Neurotransmitter release cycle","Transmission across Chemical Synapses","Neuronal System","Cellular response to hypoxia","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Developmental Biology","Aerobic respiration and respiratory electron transport","Metabolism","Extracellular matrix organization","Collagen formation","Degradation of cysteine and homocysteine","Sulfur amino acid metabolism","Signal Transduction","Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation","Cell Cycle","Disease","Collagen biosynthesis and modifying enzymes","Signaling by Rho GTPases","RHO GTPase Effectors","Metabolism of vitamins and cofactors","Epigenetic regulation of gene expression","Cellular responses to stress","Condensation of Prophase Chromosomes","Oxidative Stress Induced Senescence","Cellular Senescence","Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate","HDMs demethylate histones","Chromatin modifying enzymes","Signaling by GPCR","Class A/1 (Rhodopsin-like receptors)","Transport of small molecules","GPCR downstream signalling","NADPH regeneration","Alpha-oxidation of phytanate","Glyoxylate metabolism and glycine degradation","Peroxisomal lipid metabolism","Metabolism of proteins","G alpha (i) signalling events","SLC-mediated transmembrane transport","Organic anion transport by SLC5/17/25 transporters","Chromatin organization","GPCR ligand binding","TET1,2,3 and TDG demethylate DNA","Metabolism of lipids","Organic anion transport by SLC22 transporters","RHO GTPases activate PKNs","Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3","Diseases of metabolism","Post-translational protein modification","Respiratory electron transport","tRNA modification in the nucleus and cytosol","Synthesis of wybutosine at G37 of tRNA(Phe)","Mitotic Prophase","M Phase","Cell Cycle, Mitotic","Gluconeogenesis","Pyruvate metabolism","Glucose metabolism","Branched-chain amino acid catabolism","Lysine catabolism","Tryptophan catabolism","Carnitine synthesis","Metabolism of amino acids and derivatives","Metabolism of carbohydrates and carbohydrate derivatives","Citric acid cycle (TCA cycle)","tRNA processing","DNA Repair","DNA Damage Reversal","Reversal of alkylation damage by DNA dioxygenases","Gene expression (Transcription)","Interconversion of 2-oxoglutarate and 2-hydroxyglutarate","GABA synthesis, release, reuptake and degradation","Metabolism of RNA","Cellular responses to stimuli","Tyrosine catabolism","Phenylalanine and tyrosine metabolism","Aspartate and asparagine metabolism","Glutamate and glutamine metabolism","Alanine metabolism","Fatty acid metabolism","Metabolism of cofactors","Degradation of GABA","Protein hydroxylation","Signaling by Rho GTPases, Miro GTPases and RHOBTB3","Serine metabolism","Maternal to zygotic transition (MZT)","Chromatin modifications during the maternal to zygotic transition (MZT)","OGDH complex synthesizes succinyl-CoA from 2-OG","Malate-aspartate shuttle","SLC-mediated transport of organic anions"],"study_id_observed":["MTBLS30","MTBLS67","MTBLS87","MTBLS88"],"study_id_var_observed":["MTBLS67"],"synonym_name":"2-oxopentanedioic acid, ion(2\u2212)"}