{"chebi_id":"59560","chebi_name":"sapropterin","chebi_synonyms":["2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydoro-4(1H)-pteridinone","5,6,7,8-Tetrahydrobiopterin","(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin","(6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(3H)-one","sapropterina","sapropterinum","6R-L-5,6,7,8-tetrahydrobiopterin","(\u2212)-(6R)-2-amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(3H)-pteridinone","6R-5,6,7,8-tetrahydrobiopterin","tetrahydrobiopterin","(6R)-L-erythro-tetrahydrobiopterin","R-THBP","6R-BH4"],"diffprof_id_observed":["MTBLS1792_0001_00000018","MTBLS2384_0001_00000005","MTBLS3963_0002_00000001","MTBLS4568_0001_00000005"],"diffprof_id_var_observed":["MTBLS2384_0001_00000005"],"inchikey":"FNKQXYHWGSIFBK-RPDRRWSUSA-N","inn_name":"sapropterina","iupac_name":"(6<i>R</i>)-2-amino-6-[(1<i>R</i>,2<i>S</i>)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(3<em>H</em>)-one","num_study_observed":4,"reactome_ids":["R-HSA-1430728","R-HSA-1474151","R-HSA-162582","R-HSA-1643685","R-HSA-194138","R-HSA-196854","R-HSA-202131","R-HSA-203615","R-HSA-203641","R-HSA-203754","R-HSA-209776","R-HSA-209905","R-HSA-209931","R-HSA-2160456","R-HSA-4420097","R-HSA-5218920","R-HSA-556833","R-HSA-5668914","R-HSA-71291","R-HSA-75109","R-HSA-8939211","R-HSA-8953897","R-HSA-8963691","R-HSA-8964208","R-HSA-8978934","R-HSA-8979227","R-HSA-9006931","R-HSA-9006934","R-HSA-9009391","R-HSA-9855142","R-HSA-9856530","R-HSA-9860931"],"reactome_names":["Metabolism","Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation","Signal Transduction","Disease","Signaling by VEGF","Metabolism of vitamins and cofactors","Metabolism of nitric oxide: NOS3 activation and regulation","eNOS activation","NOSTRIN mediated eNOS trafficking","NOSIP mediated eNOS trafficking","Metabolism of amine-derived hormones","Catecholamine biosynthesis","Serotonin and melatonin biosynthesis","Phenylketonuria","VEGFA-VEGFR2 Pathway","VEGFR2 mediated vascular permeability","Metabolism of lipids","Diseases of metabolism","Metabolism of amino acids and derivatives","Triglyceride biosynthesis","ESR-mediated signaling","Cellular responses to stimuli","Phenylalanine and tyrosine metabolism","Phenylalanine metabolism","Metabolism of cofactors","Triglyceride metabolism","Signaling by Nuclear Receptors","Signaling by Receptor Tyrosine Kinases","Extra-nuclear estrogen signaling","Cellular responses to mechanical stimuli","High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells","Response of endothelial cells to shear stress"],"study_id_observed":["MTBLS1792","MTBLS2384","MTBLS3963","MTBLS4568"],"study_id_var_observed":["MTBLS2384"],"synonym_name":"2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydoro-4(1H)-pteridinone"}