{"chebi_id":"17154","chebi_name":"nicotinamide","chebi_synonyms":["3-pyridinecarboxamide","Nikotinamid","\u03b2-pyridinecarboxamide","pyridine-3-carboxamide","Vitamin PP","nicotinic acid amide","Niacinamide","Nicotins\u00e4ureamid","Nikotins\u00e4ureamid","Nicotinamid","niacin","vitamin B3","nicotine acid amide","nicotinic amide","niamide","pyridine-3-carboxylic acid amide","nicotylamide","nicotinamidum","nicotine amide","nicotinamida","m-(aminocarbonyl)pyridine","3-carbamoylpyridine"],"diffprof_id_observed":["MTBLS125_0001_00000005","MTBLS125_0002_00000005","MTBLS127_0001_00000027","MTBLS127_0002_00000027","MTBLS127_0003_00000002","MTBLS127_0004_00000002","MTBLS127_0005_00000002","MTBLS127_0005_00000027","MTBLS1550_0001_00000001","MTBLS159_0001_00000001","MTBLS159_0002_00000001","MTBLS159_0003_00000001","MTBLS159_0004_00000001","MTBLS181_0001_00000002","MTBLS1831_0001_00000001","MTBLS1847_0001_00000001","MTBLS1858_0001_00000001","MTBLS1980_0001_00000001","MTBLS2015_0001_00000001","MTBLS2108_0002_00000001","MTBLS2145_0001_00000029","MTBLS2145_0002_00000029","MTBLS2145_0006_00000029","MTBLS214_0001_00000002","MTBLS214_0003_00000002","MTBLS2279_0001_00000005","MTBLS2322_0001_00000001","MTBLS2323_0001_00000001","MTBLS2324_0001_00000001","MTBLS2406_0002_00000009","MTBLS2559_0001_00000001","MTBLS2688_0002_00000001","MTBLS2871_0002_00000009","MTBLS2878_0002_00000001","MTBLS3003_0002_00000001","MTBLS3056_0002_00000001","MTBLS312_0002_00000009","MTBLS353_0001_00000001","MTBLS360_0001_00000001","MTBLS360_0002_00000001","MTBLS3628_0001_00000004","MTBLS3637_0002_00000001","MTBLS3657_0001_00000003","MTBLS3725_0002_00000003","MTBLS3750_0001_00000006","MTBLS3886_0002_00000004","MTBLS3927_0001_00000001","MTBLS3927_0002_00000001","MTBLS3935_0001_00000003","MTBLS4046_0002_00000014","MTBLS4099_0001_00000001","MTBLS4186_0002_00000001","MTBLS4387_0003_00000001","MTBLS4463_0001_00000001","MTBLS4568_0001_00000005","MTBLS4579_0001_00000001","MTBLS4820_0002_00000001","MTBLS4893_0001_00000003","MTBLS4893_0002_00000003","MTBLS4932_0001_00000005","MTBLS4967_0002_00000003","MTBLS4980_0002_00000006","MTBLS522_0001_00000002","MTBLS533_0001_00000001","MTBLS5462_0001_00000002","MTBLS5462_0001_00000089","MTBLS5462_0001_00000119","MTBLS5462_0001_00000152","MTBLS549_0001_00000006","MTBLS5828_0002_00000001","MTBLS5971_0001_00000001","MTBLS627_0001_00000001","MTBLS6337_0001_00000002","MTBLS633_0001_00000001","MTBLS6402_0002_00000001","MTBLS6516_0002_00000002","MTBLS656_0001_00000031","MTBLS6603_0002_00000001","MTBLS6661_0002_00000001","MTBLS6736_0002_00000001","MTBLS6758_0002_00000002","MTBLS686_0001_00000001","MTBLS6886_0004_00000001","MTBLS6927_0002_00000001","MTBLS739_0001_00000001","MTBLS7584_0001_00000003","MTBLS7584_0003_00000003","MTBLS7711_0001_00000003","MTBLS7713_0001_00000003","MTBLS789_0001_00000001","MTBLS795_0001_00000001","MTBLS809_0002_00000001","MTBLS87_0001_00000001","MTBLS87_0003_00000001","MTBLS87_0005_00000001","MTBLS88_0002_00000001","MTBLS88_0004_00000001"],"diffprof_id_var_observed":["MTBLS1550_0001_00000001","MTBLS1980_0001_00000001","MTBLS2108_0002_00000001","MTBLS2145_0002_00000029","MTBLS2145_0006_00000029","MTBLS214_0001_00000002","MTBLS214_0003_00000002","MTBLS2322_0001_00000001","MTBLS2323_0001_00000001","MTBLS2324_0001_00000001","MTBLS2406_0002_00000009","MTBLS2871_0002_00000009","MTBLS3056_0002_00000001","MTBLS3628_0001_00000004","MTBLS3657_0001_00000003","MTBLS3886_0002_00000004","MTBLS4387_0003_00000001","MTBLS4820_0002_00000001","MTBLS4893_0001_00000003","MTBLS4893_0002_00000003","MTBLS6402_0002_00000001","MTBLS6736_0002_00000001","MTBLS6758_0002_00000002","MTBLS6886_0004_00000001","MTBLS809_0002_00000001","MTBLS87_0001_00000001","MTBLS87_0003_00000001","MTBLS87_0005_00000001","MTBLS88_0002_00000001","MTBLS88_0004_00000001"],"inchikey":"DFPAKSUCGFBDDF-UHFFFAOYSA-N","inn_name":"nicotinamide","iupac_name":"pyridine-3-carboxamide","num_study_observed":75,"reactome_ids":["R-HSA-110362","R-HSA-110373","R-HSA-1257604","R-HSA-1266738","R-HSA-1428517","R-HSA-1430728","R-HSA-1592230","R-HSA-162582","R-HSA-1640170","R-HSA-1643685","R-HSA-170834","R-HSA-1852241","R-HSA-195721","R-HSA-196807","R-HSA-196849","R-HSA-196854","R-HSA-201681","R-HSA-204174","R-HSA-212165","R-HSA-212436","R-HSA-2151201","R-HSA-2173793","R-HSA-2173795","R-HSA-2262752","R-HSA-2408508","R-HSA-2408522","R-HSA-2555396","R-HSA-2995383","R-HSA-2995410","R-HSA-3371453","R-HSA-3371556","R-HSA-427359","R-HSA-4641257","R-HSA-5250941","R-HSA-5336415","R-HSA-5339562","R-HSA-5663205","R-HSA-5685939","R-HSA-5693532","R-HSA-5693538","R-HSA-5693567","R-HSA-5693607","R-HSA-5696394","R-HSA-5696398","R-HSA-5696399","R-HSA-6807070","R-HSA-68882","R-HSA-68886","R-HSA-69278","R-HSA-70268","R-HSA-71291","R-HSA-71403","R-HSA-73857","R-HSA-73884","R-HSA-73894","R-HSA-73933","R-HSA-74160","R-HSA-8948751","R-HSA-8953897","R-HSA-9006925","R-HSA-9006936","R-HSA-9614085","R-HSA-9617629","R-HSA-9635486","R-HSA-9637679","R-HSA-9637698","R-HSA-9640148","R-HSA-9678108","R-HSA-9679506","R-HSA-9683610","R-HSA-9683701","R-HSA-9694516","R-HSA-9694631","R-HSA-9694635","R-HSA-9730414","R-HSA-9772573","R-HSA-9824439","R-HSA-9824446","R-HSA-9854311","R-HSA-9856649","R-HSA-9861718","R-HSA-9956593"],"reactome_names":["POLB-Dependent Long Patch Base Excision Repair","Resolution of AP sites via the multiple-nucleotide patch replacement pathway","PIP3 activates AKT signaling","Developmental Biology","Aerobic respiration and respiratory electron transport","Metabolism","Mitochondrial biogenesis","Signal Transduction","Cell Cycle","Disease","Signaling by TGF-beta Receptor Complex","Organelle biogenesis and maintenance","Signaling by WNT","Nicotinate metabolism","Metabolism of water-soluble vitamins and cofactors","Metabolism of vitamins and cofactors","TCF dependent signaling in response to WNT","Regulation of pyruvate dehydrogenase (PDH) complex","Epigenetic regulation of gene expression","Generic Transcription Pathway","Transcriptional activation of mitochondrial biogenesis","Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer","Downregulation of SMAD2/3:SMAD4 transcriptional activity","Cellular responses to stress","Metabolism of ingested SeMet, Sec, MeSec into H2Se","Selenoamino acid metabolism","Mitotic Metaphase and Anaphase","Initiation of Nuclear Envelope (NE) Reformation","Nuclear Envelope (NE) Reassembly","Regulation of HSF1-mediated heat shock response","Cellular response to heat stress","SIRT1 negatively regulates rRNA expression","Degradation of AXIN","Negative epigenetic regulation of rRNA expression","Uptake and function of diphtheria toxin","Uptake and actions of bacterial toxins","Infectious disease","HDR through MMEJ (alt-NHEJ)","DNA Double-Strand Break Repair","Homology Directed Repair","HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","Processing of DNA double-strand break ends","DNA Damage Recognition in GG-NER","Nucleotide Excision Repair","Global Genome Nucleotide Excision Repair (GG-NER)","PTEN Regulation","Mitotic Anaphase","M Phase","Cell Cycle, Mitotic","Pyruvate metabolism","Metabolism of amino acids and derivatives","Citric acid cycle (TCA cycle)","RNA Polymerase II Transcription","Base Excision Repair","DNA Repair","Resolution of Abasic Sites (AP sites)","Gene expression (Transcription)","Regulation of PTEN stability and activity","Cellular responses to stimuli","Intracellular signaling by second messengers","Signaling by TGFB family members","FOXO-mediated transcription","Regulation of FOXO transcriptional activity by acetylation","Infection with Mycobacterium tuberculosis","Escape of Mtb from the phagocyte","Phagocyte cell death caused by cytosolic Mtb","Infection with Enterobacteria","SARS-CoV-1 Infection","SARS-CoV Infections","Maturation of nucleoprotein","Translation of Structural Proteins","SARS-CoV-2 Infection","Maturation of nucleoprotein","Translation of Structural Proteins","MITF-M-regulated melanocyte development","Late SARS-CoV-2 Infection Events","Bacterial Infection Pathways","Viral Infection Pathways","Maturation of TCA enzymes and regulation of TCA cycle","Transcriptional and post-translational regulation of MITF-M expression and activity","Regulation of pyruvate metabolism","Microbial factors inhibit CASP4 activity"],"study_id_observed":["MTBLS125","MTBLS127","MTBLS1550","MTBLS159","MTBLS181","MTBLS1831","MTBLS1847","MTBLS1858","MTBLS1980","MTBLS2015","MTBLS2108","MTBLS214","MTBLS2145","MTBLS2279","MTBLS2322","MTBLS2323","MTBLS2324","MTBLS2406","MTBLS2559","MTBLS2688","MTBLS2871","MTBLS2878","MTBLS3003","MTBLS3056","MTBLS312","MTBLS353","MTBLS360","MTBLS3628","MTBLS3637","MTBLS3657","MTBLS3725","MTBLS3750","MTBLS3886","MTBLS3927","MTBLS3935","MTBLS4046","MTBLS4099","MTBLS4186","MTBLS4387","MTBLS4463","MTBLS4568","MTBLS4579","MTBLS4820","MTBLS4893","MTBLS4932","MTBLS4967","MTBLS4980","MTBLS522","MTBLS533","MTBLS5462","MTBLS549","MTBLS5828","MTBLS5971","MTBLS627","MTBLS633","MTBLS6337","MTBLS6402","MTBLS6516","MTBLS656","MTBLS6603","MTBLS6661","MTBLS6736","MTBLS6758","MTBLS686","MTBLS6886","MTBLS6927","MTBLS739","MTBLS7584","MTBLS7711","MTBLS7713","MTBLS789","MTBLS795","MTBLS809","MTBLS87","MTBLS88"],"study_id_var_observed":["MTBLS1550","MTBLS1980","MTBLS2108","MTBLS214","MTBLS2145","MTBLS2322","MTBLS2323","MTBLS2324","MTBLS2406","MTBLS2871","MTBLS3056","MTBLS3628","MTBLS3657","MTBLS3886","MTBLS4387","MTBLS4820","MTBLS4893","MTBLS6402","MTBLS6736","MTBLS6758","MTBLS6886","MTBLS809","MTBLS87","MTBLS88"],"synonym_name":"\u03b2-pyridinecarboxamide"}