{"chebi_id":"29033","chebi_name":"iron(2+)","chebi_synonyms":["iron ion(2+)","Iron(2+)","Ferrous ion","Fe(II)","Fe2+","FE (II) ION","iron(II) cation","iron(2+) ion"],"diffprof_id_observed":["MTBLS1550_0001_00000001"],"diffprof_id_var_observed":["MTBLS1550_0001_00000001"],"inchikey":"CWYNVVGOOAEACU-UHFFFAOYSA-N","inn_name":"","iupac_name":"iron(2+)","num_study_observed":1,"reactome_ids":["R-HSA-111885","R-HSA-112122","R-HSA-112126","R-HSA-1222387","R-HSA-1222449","R-HSA-1222499","R-HSA-1222556","R-HSA-1234174","R-HSA-1234176","R-HSA-1237112","R-HSA-1266738","R-HSA-1362409","R-HSA-1428517","R-HSA-1430728","R-HSA-1474151","R-HSA-1474244","R-HSA-1474290","R-HSA-1483249","R-HSA-15869","R-HSA-1614558","R-HSA-1614635","R-HSA-162582","R-HSA-163841","R-HSA-1640170","R-HSA-1643685","R-HSA-1650814","R-HSA-1660661","R-HSA-168249","R-HSA-168256","R-HSA-180024","R-HSA-1855183","R-HSA-189445","R-HSA-189451","R-HSA-189483","R-HSA-192105","R-HSA-194068","R-HSA-196854","R-HSA-204626","R-HSA-209776","R-HSA-209905","R-HSA-209931","R-HSA-212165","R-HSA-2142688","R-HSA-2142691","R-HSA-2142696","R-HSA-2142700","R-HSA-2142712","R-HSA-2142753","R-HSA-2142770","R-HSA-2142789","R-HSA-2160456","R-HSA-2187338","R-HSA-2262752","R-HSA-2299718","R-HSA-2559580","R-HSA-2559583","R-HSA-372790","R-HSA-382551","R-HSA-388396","R-HSA-389599","R-HSA-390918","R-HSA-392499","R-HSA-418594","R-HSA-425407","R-HSA-425410","R-HSA-428157","R-HSA-5221030","R-HSA-556833","R-HSA-5619048","R-HSA-5619049","R-HSA-5619060","R-HSA-5619102","R-HSA-5619115","R-HSA-5663205","R-HSA-5668914","R-HSA-597592","R-HSA-6782315","R-HSA-6782861","R-HSA-6803157","R-HSA-6803544","R-HSA-6806667","R-HSA-68875","R-HSA-68886","R-HSA-69278","R-HSA-71240","R-HSA-71262","R-HSA-71291","R-HSA-71336","R-HSA-71387","R-HSA-71403","R-HSA-72306","R-HSA-73817","R-HSA-73894","R-HSA-73942","R-HSA-73943","R-HSA-74160","R-HSA-8941413","R-HSA-8953854","R-HSA-8953897","R-HSA-8956320","R-HSA-8957322","R-HSA-8963684","R-HSA-8963691","R-HSA-8964208","R-HSA-8978868","R-HSA-8978934","R-HSA-9018677","R-HSA-9018678","R-HSA-9018683","R-HSA-9025094","R-HSA-9025106","R-HSA-9026290","R-HSA-917937","R-HSA-917977","R-HSA-9629569","R-HSA-9635486","R-HSA-9638334","R-HSA-9638482","R-HSA-9640148","R-HSA-9707564","R-HSA-9709957","R-HSA-9711123","R-HSA-975634","R-HSA-9816359","R-HSA-9821002","R-HSA-9824439","R-HSA-9854311"],"reactome_names":["Opioid Signalling","ALKBH2 mediated reversal of alkylation damage","ALKBH3 mediated reversal of alkylation damage","Tolerance of reactive oxygen produced by macrophages","Mtb iron assimilation by chelation","Latent infection - Other responses of Mtb to phagocytosis","ROS and RNS production in phagocytes","Cellular response to hypoxia","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Methionine salvage pathway","Developmental Biology","Mitochondrial iron-sulfur cluster biogenesis","Aerobic respiration and respiratory electron transport","Metabolism","Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation","Extracellular matrix organization","Collagen formation","Inositol phosphate metabolism","Metabolism of nucleotides","Degradation of cysteine and homocysteine","Sulfur amino acid metabolism","Signal Transduction","Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation","Cell Cycle","Disease","Collagen biosynthesis and modifying enzymes","Sphingolipid de novo biosynthesis","Innate Immune System","Immune System","DARPP-32 events","Synthesis of IP2, IP, and Ins in the cytosol","Metabolism of porphyrins","Heme biosynthesis","Heme degradation","Synthesis of bile acids and bile salts","Bile acid and bile salt metabolism","Metabolism of vitamins and cofactors","Hypusine synthesis from eIF5A-lysine","Metabolism of amine-derived hormones","Catecholamine biosynthesis","Serotonin and melatonin biosynthesis","Epigenetic regulation of gene expression","Synthesis of 5-eicosatetraenoic acids","Synthesis of Leukotrienes (LT) and Eoxins (EX)","Synthesis of Hepoxilins (HX) and Trioxilins (TrX)","Biosynthesis of Lipoxins (LX)","Synthesis of 12-eicosatetraenoic acid derivatives","Arachidonate metabolism","Synthesis of 15-eicosatetraenoic acid derivatives","Ubiquinol biosynthesis","Phenylketonuria","Visual phototransduction","Cellular responses to stress","Condensation of Prophase Chromosomes","Oxidative Stress Induced Senescence","Cellular Senescence","Signaling by GPCR","Transport of small molecules","GPCR downstream signalling","Alpha-oxidation of phytanate","Peroxisomal lipid metabolism","Metabolism of proteins","G alpha (i) signalling events","SLC-mediated transmembrane transport","Metal ion SLC transporters","Sphingolipid metabolism","TET1,2,3 and TDG demethylate DNA","Metabolism of lipids","Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1)","Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages)","Defective CP causes aceruloplasminemia (ACERULOP)","SLC transporter disorders","Disorders of transmembrane transporters","Infectious disease","Diseases of metabolism","Post-translational protein modification","tRNA modification in the nucleus and cytosol","Synthesis of wybutosine at G37 of tRNA(Phe)","Antimicrobial peptides","Ion influx/efflux at host-pathogen interface","Metabolism of fat-soluble vitamins","Mitotic Prophase","M Phase","Cell Cycle, Mitotic","Tryptophan catabolism","Carnitine synthesis","Metabolism of amino acids and derivatives","Pentose phosphate pathway","Metabolism of carbohydrates and carbohydrate derivatives","Citric acid cycle (TCA cycle)","tRNA processing","Purine ribonucleoside monophosphate biosynthesis","DNA Repair","DNA Damage Reversal","Reversal of alkylation damage by DNA dioxygenases","Gene expression (Transcription)","Events associated with phagocytolytic activity of PMN cells","Metabolism of RNA","Cellular responses to stimuli","Nucleotide biosynthesis","Metabolism of steroids","Tyrosine catabolism","Phenylalanine and tyrosine metabolism","Phenylalanine metabolism","Fatty acid metabolism","Metabolism of cofactors","Biosynthesis of DHA-derived SPMs","Biosynthesis of specialized proresolving mediators (SPMs)","Biosynthesis of DPA-derived SPMs","Biosynthesis of DPAn-3 SPMs","Biosynthesis of DPAn-6 SPMs","Biosynthesis of DPAn-3-derived maresins","Iron uptake and transport","Transferrin endocytosis and recycling","Protein hydroxylation","Infection with Mycobacterium tuberculosis","Iron assimilation using enterobactin","Metal ion assimilation from the host","Infection with Enterobacteria","Cytoprotection by HMOX1","Sensory Perception","Cellular response to chemical stress","Retinoid metabolism and transport","Maternal to zygotic transition (MZT)","Chromatin modifications during the maternal to zygotic transition (MZT)","Bacterial Infection Pathways","Maturation of TCA enzymes and regulation of TCA cycle"],"study_id_observed":["MTBLS1550"],"study_id_var_observed":["MTBLS1550"],"synonym_name":"Ferrous ion"}