{"chebi_id":"49603","chebi_name":"lapatinib","chebi_synonyms":["N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE","N-[3-chloro-4-(3-fluorobenzyloxy)phenyl]-6-[5-({[2-(methanesulfonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine","N-(3-chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine","Tykerb","GW 572016"],"diffprof_id_observed":["MTBLS1411_0001_00000001","MTBLS1411_0002_00000001"],"diffprof_id_var_observed":["MTBLS1411_0001_00000001","MTBLS1411_0002_00000001"],"inchikey":"BCFGMOOMADDAQU-UHFFFAOYSA-N","inn_name":"","iupac_name":"<em>N</em>-[3-chloro-4-(3-fluorobenzyloxy)phenyl]-6-[5-({[2-(methanesulfonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine","num_study_observed":1,"reactome_ids":["R-HSA-1227986","R-HSA-1227990","R-HSA-1236382","R-HSA-162582","R-HSA-1643685","R-HSA-1643713","R-HSA-5637815","R-HSA-5663202","R-HSA-9006934","R-HSA-9634285","R-HSA-9652282","R-HSA-9664565","R-HSA-9665230","R-HSA-9665251","R-HSA-9665348","R-HSA-9665686"],"reactome_names":["Signaling by ERBB2","Signaling by ERBB2 in Cancer","Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants","Signal Transduction","Disease","Signaling by EGFR in Cancer","Signaling by Ligand-Responsive EGFR Variants in Cancer","Diseases of signal transduction by growth factor receptors and second messengers","Signaling by Receptor Tyrosine Kinases","Constitutive Signaling by Overexpressed ERBB2","Drug-mediated inhibition of ERBB2 signaling","Signaling by ERBB2 KD Mutants","Drug resistance in ERBB2 KD mutants","Resistance of ERBB2 KD mutants to lapatinib","Signaling by ERBB2 ECD mutants","Signaling by ERBB2 TMD/JMD mutants"],"study_id_observed":["MTBLS1411"],"study_id_var_observed":["MTBLS1411"],"synonym_name":"N-(3-chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine"}